Blood clots is a result of blood solidification and you can unusual viscosity because of barriers impacting their fluidity; which results in the formation of thrombocytes and you may activation out-of blood coagulation foundation (8–10). Thus, fixing bloodstream viscosity and you can boosting bloodstream coagulation setting indexes enjoys a keen crucial part regarding prevention and you may treatments for DVT.
Our study indicated that getting 3 days and you will 10 days immediately after DVT acting, hemorheology and coagulation indexes had been an informed on the highest-amount folic acid and nutritional B12 category. Certain account has advised you to Hcy try good thrombus-developing representative, and you will highest Hcy you’ll cause deep venous thrombosis (14–17). While doing so, plasma D-dimer could have been advised for a forewarning form getting thrombus and you can hypercoagulable condition (18,19). Ten months after DVT modeling, i unearthed that the levels out-of Hcy and you can D-dimer improved the essential regarding the high-amount group.
By way of histopathologic test, we found that 10 weeks shortly after DVT acting the large-dosage and you can reduced-dose teams displayed extreme change in the change out-of all the way down extremity strong venous thrombosis. Deep venous thrombosis away from all the way down extremity that have color Doppler ultrasound diagnosis has some positives, eg easy process, defense and you may energy-efficient, inexpensive, repeatability and you may head observation, plus the detection from relevant lesions and you may bleeding keeps to bloodstream vessels (20). The show also revealed that just after DVT modeling, the newest energetic rates from all the way down extremity strong venous thrombosis treatments for high-serving class try 100%. The outcomes away from color Doppler ultrasound diagnosis regarding DVT corresponded so you’re able to all of our findings inside the histopathologic test. This verified new feasibility and you can energy-efficient from color Doppler ultrasound prognosis for strong venous thrombosis of the down extremity.
From inside the sumin B12 has clear therapeutic consequences for the a bunny model away from DVT which have hyperhomocysteinemia. The new high-dosage i tried increased certain relevant attacks, including the levels of Hcy and you can D-dimer, hemorheology, coagulation setting, and you can vein pathology. Total, this research support the entry to highest amounts off folic acid and you will supplement B12 to treat DVT.
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